Article

Fto in the hippocampus mediates depression-like behaviors

2021-02-17

Abstract excerpt

Dynamic and reversible RNA methylation has emerged as a new layer of epigenetic regulation of behaviors such as learning and memory; however, whether RNA methylation plays a critical role in the pathophysiology of depression is unclear. Here, we report that expression of the fat mass and obesity associated gene (FTO), a primary RNA demethylase, is downregulated in the hippocampi of both major depressive disorder (...

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Literature Corpus work: 18f923e5-fc32-52e9-bee8-ac5ac1b396ae
DOI: 10.21203/rs.3.rs-194104/v1

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