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Article

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

27 Jun 2016

Abstract excerpt

Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line rats (FSL). After acute stress during...

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PMID: 27354525
DOI: 10.1073/pnas.1603111113

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