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Article

Stress modulates Ahi1-dependent nuclear localization of ten-eleven translocation protein 2.

Human molecular genetics - 1 Nov 2021

Zhang Qian, Hu Qicheng, Wang Junjie, Miao Zhigang, Li Ziyi, Zhao Yuwen, Wan Bo, Allen Emily G, Sun Miao, Jin Peng, Xu Xingshun

Abstract excerpt

Major depression disorder is one of the most common psychiatric diseases. Recent evidence supports that environmental stress affects gene expression and promotes the pathological process of depression through epigenetic mechanisms. Three ten-eleven translocation (Tet) enzymes are epigenetic regulators of gene expression that promote 5-hydroxymethylcytosine (5hmC) modification of genes. Here, we show that the loss...

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PMID: 34218273
DOI: 10.1093/hmg/ddab179
PMCID: PMC8837822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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