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Article

Investigating the genetic basis of fibrotic pathway dysregulation in Dupuytren's contracture.

Connective tissue research - 1 Jul 2026

Vilkeviciute-Petraite Alvita, Basalykiene Dovile, Baltakyte Migdolija, Kunceviciene Edita, Pileckaite Enrika, Samulenas Gediminas, Smalinskiene Alina

Abstract excerpt

PURPOSE: Dupuytren's contracture (DC) is a common fibroproliferative disorder with strong genetic predisposition. This study aimed to investigate the association between genetic variants in key fibrotic pathways and DC susceptibility in a Lithuanian population. MATERIALS AND METHODS: We conducted a case-control study including 116 patients with DC and 103 healthy controls. Genotyping of four single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42223124
DOI: 10.1080/03008207.2026.2680153

Genes

SFRP4
COL1A1
TAB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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