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Article

Dupuytren's disease: a localised and accessible human fibrotic disorder

23 Dec 2022

Abstract excerpt

We review the biology of Dupuytren's disease (DD), a common localised fibrotic disorder of the hand. The disease develops through a complex interplay of genetic and environmental factors, and epigenetic signalling. The early-stage disease nodules comprise a complex milieu of stromal and immune cells which interact to promote disease development. Recently, inhibition of tumour necrosis factor (TNF) locally...

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PMID: 36566101
DOI: 10.1016/j.molmed.2022.12.001

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