Article

Investigating the Relationship Between Rare Genetic Variants and Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease

2024-03-04

Abstract excerpt

<h4>Background and Aims</h4> Nonalcoholic Fatty Liver Disease (NAFLD) is a complex human disease. Common genetic variation in the patatin-like phospholipase domain containing 3 ( PNPLA3 ) and transmembrane 6 superfamily member 2 ( TM6SF2 ) genes have been associated with an increased risk of developing NAFLD, nonalcoholic steatohepatitis (NASH), and fibrosis in adults. The role of rare genetic variants in the deve...

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Literature Corpus work: 186b7d0b-0afc-54f8-a222-eebfc7a38d45
DOI: 10.1101/2024.03.02.24303632

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