Article
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) - 1 Sept 2010
Rotman Yaron, Koh Christopher, Zmuda Joseph M, Kleiner David E, Liang T Jake
Abstract excerpt
UNLABELLED: Genome-wide association studies identified single-nucleotide polymorphisms (SNPs) that are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting nonalcoholic fatty liver disease (NAFLD). To investigate whether these SNPs are associated with histological severity of NAFLD, 1117 (894 adults/223 children) individuals enrolled in the Nonalcoholic Steatohepatitis (NASH)...
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