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Article

Overactive PDGFRα and PDGFRβ promote distinct phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving muscle growth.

American journal of physiology. Cell physiology - 1 May 2026

Gimla Mariola, Olszewski Szczepan, Brown Jacob L, Raymond-Pope Christiana J, Rigsby Sandra, Peelor Frederick F, Kwon Hae Ryong, Yao Longbiao, Olson Lorin E, Fuqua Jordan D, Miller Benjamin F

Abstract excerpt

Fibrosis accumulates in skeletal muscle over time and leads to greater muscle rigidity, stiffness, and increased risk of injuries. However, investigations of appropriate experimental models to study the mechanisms through which muscle fibrosis occurs are often confounded by injury or disease. The contribution of platelet-derived growth factor receptors alpha and beta (PDGFRα or PDGFRβ) to muscle fibrosis is yet...

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PMID: 41979571
DOI: 10.1152/ajpcell.00035.2026
PMCID: PMC13206643

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