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Human Immunodeficiency Virus Type 1 Vpr-Mediated G<sub>2</sub> Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation

14 Oct 2004

Abstract excerpt

Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the event of irreparable damage, commitment to apoptosis. Under conditions of replication stress, the damage signal is initiated by the ataxia-telangiectasia-mutated and Rad3-related kinase ATR. We recently demonstrated...

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PMID: 15485898
DOI: 10.1128/mcb.24.21.9286-9294.2004

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