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Article

Viruses and the DNA Damage Response: Activation and Antagonism

18 Jul 2014

Abstract excerpt

Viruses must interact with their hosts in order to replicate; these interactions often provoke the evolutionarily conserved response to DNA damage, known as the DNA damage response (DDR). The DDR can be activated by incoming viral DNA, during the integration of retroviruses, or in response to the aberrant DNA structures generated upon replication of DNA viruses. Furthermore, DNA and RNA viral proteins can induce...

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PMID: 26958736
DOI: 10.1146/annurev-virology-031413-085548

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