Article

Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor

2019-04-17

Abstract excerpt

An acidic milieu is a hallmark of the glycolytic metabolism that occurs in cancerous cells. The acidic environment is known to promote cancer progression, but the underlying signaling and cell biological underpinnings of these phenomena are not well understood. Here, we describe ogremorphin, a first-in-class small-molecule inhibitor of GPR68, an extracellular proton-sensing and mechanosensing G protein–coupled rec...

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Literature Corpus work: 17feba02-7113-5719-bfd0-3ed4694fefcf
DOI: 10.1101/612549

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