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Article

Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.

Pigment cell & melanoma research - 1 Jan 2018

Neto Ana, Ceol Craig J

Abstract excerpt

Large-scale sequencing studies have revealed several genes that are recurrently mutated in melanomas. To annotate the melanoma genome, we have expressed tumor-associated variants of these genes in zebrafish and characterized their effects on melanocyte development and function. Here, we describe expression of tumor-associated variants of the recurrently mutated metabotropic glutamate receptor 3 (GRM3) gene....

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Source

Identifiers

PMID: 28646617
DOI: 10.1111/pcmr.12610

Genes

GRM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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