Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

Abstract excerpt

Drug resistance is an almost inevitable consequence of cancer therapy and ultimately proves fatal for the majority of patients. In many cases this is the consequence of specific gene mutations that have the potential to be targeted to re-sensitize the tumor. The ability to uniformly saturate the genome with point mutations without chromosome or nucleotide sequence context bias would open the door to identify all p...

Topics

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• Antineoplastic Agents
• CRISPR and Genetic Engineering
• Genomics
• High-Throughput Nucleotide Sequencing
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Precision Medicine

Identifiers and source

Literature Corpus work

f6b88bc3-4e7b-581b-b0a1-26da405923f5

DOI

10.1101/066555