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Article

Genome-wide screen for anticancer drug resistance in haploid human embryonic stem cells.

Cell proliferation - 1 Jun 2023

Segal Emanuel, Nissenbaum Jonathan, Peretz Mordecai, Golan-Lev Tamar, Cashman Rivki, Philip Hagit, Reubinoff Benjamin E, Kopper Oded, Benvenisty Nissim

Abstract excerpt

Anticancer drugs are at the frontline of cancer therapy. However, innate resistance to these drugs occurs in one-third to one-half of patients, exposing them to the side effects of these drugs with no meaningful benefit. To identify the genes and pathways that confer resistance to such therapies, we performed a genome-wide screen in haploid human embryonic stem cells (hESCs). These cells possess the advantage of...

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Identifiers

PMID: 37086010
DOI: 10.1111/cpr.13475
PMCID: PMC10280149

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