Resistance patterns in drug-adapted cancer cell lines reflect the complex evolution in clinical tumours

Abstract excerpt

<h4>Background</h4> Here, we introduce a novel set of triple-negative breast cancer (TNBC) cell lines consisting of MDA-MB-468, HCC38, and HCC1806 and their sublines adapted to cisplatin, doxorubicin, eribulin, paclitaxel, gemcitabine, or 5-fluorouracil. <h4>Methods</h4> The cell lines were characterized by whole exome sequencing and the determination of drug-response profiles. Moreover, genes harbouring resista...

Topics

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• Breast Neoplasms
• Cells, Cultured
• Clonal Evolution
• Drug Resistance, Neoplasm
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• High-Throughput Nucleotide Sequencing
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

8246f63b-93aa-56fd-9d4c-5df1c90262ee

DOI

10.1101/2024.01.20.576412