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Article

Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007

Tingley Whittemore G, Pawlikowska Ludmila, Zaroff Jonathan G, Kim Taeryn, Nguyen Trieu, Young Stephen G, Vranizan Karen, Kwok Pui-Yan, Whooley Mary A, Conklin Bruce R

Abstract excerpt

Sudden cardiac death due to abnormal heart rhythm kills 400,000-460,000 Americans each year. To identify genes that regulate heart rhythm, we are developing a screen that uses mouse embryonic stem cells (mESCs) with gene disruptions that can be differentiated into cardiac cells for phenotyping. Here, we show that the heterozygous disruption of the Akap10 (D-AKAP2) gene that disrupts the final 51 aa increases the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17485678
DOI: 10.1073/pnas.0610393104
PMCID: PMC1866184

Genes

AKAP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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