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In Vivo Ryr 2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia

28 Sept 2018

Abstract excerpt

Rationale: Autosomal-dominant mutations in ryanodine receptor type 2 ( RYR2 ) are responsible for ≈60% of all catecholaminergic polymorphic ventricular tachycardia. Dysfunctional RyR2 subunits trigger inappropriate calcium leak from the tetrameric channel resulting in potentially lethal ventricular tachycardia. In vivo CRISPR/Cas9-mediated gene editing is a promising strategy that could be used to eliminate the...

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PMID: 30355031
DOI: 10.1161/circresaha.118.313369

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