Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology

8 Aug 2016

Abstract excerpt

Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia (SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and autonomic dysfunction have all been described, but a unifying pathophysiology and mechanism explaining the poor prognosis and propensity to sudden death has been elusive. Herein, SCA mice underwent a longitudinal comprehensive cardiac...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Hemoglobinopathies and Related Disorders
Share to Iron Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27503873
DOI: 10.1073/pnas.1600311113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiologyPMID 27503873Read ↗

Cardiorespiratory pathogenesis of sickle cell disease in a mouse model.Semantic proximity Read ↗

Heart Failure in Haemoglobinopathies: Pathophysiology, Clinical Phenotypes, and ManagementSemantic proximity Read ↗

The Pattern of Cardiac Remodeling in Pediatric and Adolescent Patients with Sickle Cell Disease and the Association with the Genotype and the Clinical Severity of the Disease: A Systematic ReviewSemantic proximity Read ↗

Sickle Cell Disease and the HeartSemantic proximity Read ↗

Cardiac manifestations in sickle cell disease varies with patient genotype.Semantic proximity Read ↗

Evidence for a novel mechanism independent of myocardial iron in β-thalassemia cardiac pathogenesis.Semantic proximity Read ↗

Cardiovascular complications of sickle cell disease.Semantic proximity Read ↗

Pulmonary complications of hemoglobinopathies.Semantic proximity Read ↗

Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.Semantic proximity Read ↗

Multi-Organ Morphological Findings in a Humanized Murine Model of Sickle Cell TraitSemantic proximity Read ↗

<span class="word">Exploring <span class="word"><span class="changedDisabled">Molecular <span class="word"><span class="changedDisabled">Aspects <span class="word">of <span class="word"><span class="changedDisabled">Cardiovascular <span class="word"><span class="changedDisabled">Diseases <span class="word">on <span class="word"><span class="changedDisabled">Animal <span class="word"><span class="changedDisabled">ModelsSemantic proximity Read ↗

Human heart organoids reveal a regenerative strategy for mitochondrial diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.