Article

Efficacy and safety of an mRNA-based RSV preF vaccine in preclinical studies

2024-10-01

Abstract excerpt

The transmembrane fusion (F) protein of RSV plays important roles in RSV pathogenesis as it mediates the fusion between virus and the target cell membrane. During the fusion process, F protein transits from a metastable state (prefusion, preF) to a stable state after merging of virus and cell membranes (postfusion, postF). The majority of highly neutralizing antibodies induced by natural infection or immunization...

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Literature Corpus work: 17de8f2d-b595-5041-9488-1ea11a5f7149
DOI: 10.1101/2024.09.29.615646

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