Article

Spatial transcriptomics reveals substantial heterogeneity in triple negative breast cancer with potential clinical implications

2024-02-19

Abstract excerpt

<title>Abstract</title> <p>While triple negative breast cancer (TNBC) is known to be heterogeneous at the genomic and transcriptomic levels, spatial information on tumor organization and cell composition is still lacking. Here, we investigated TNBC tumor architecture including its microenvironment using spatial transcriptomics on a series of 92 patients. We performed an in-depth characterization of tumor and stro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 981bbb14-4145-584b-ab5a-6a7d620892f4
DOI: 10.21203/rs.3.rs-3921508/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics reveals substantial heterogeneity in triple negative breast cancer with potential clinical implicationsDOI 10.21203/rs.3.rs-3921508/v1Read

Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implicationsSemantic proximity Read

Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast CancerSemantic proximity Read

Spatial Logic Reconciles Gene-signature Methods in Triple Negative Breast CancerSemantic proximity Read

Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancerSemantic proximity Read

A High-Dimensional Window into the Micro-Environment of Triple Negative Breast CancerSemantic proximity Read

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast CancerSemantic proximity Read

Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment ApproachSemantic proximity Read

Targeted spatial profiling identifies a CD8A − LARS axis associated with neoadjuvant chemotherapy resistance in triple-negative breast cancerSemantic proximity Read

Spatial Transcriptomic Profiling Uncovers Tumor Heterogeneity and Microenvironmental Features Associated with Lymph Node Metastasis in Invasive Lobular CarcinomaSemantic proximity Read

Spatial transcriptomics in breast cancer: providing insight into tumor heterogeneity and promoting individualized therapySemantic proximity Read

Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular RelationshipsSemantic proximity Read

Clonal expansion of intra‐epithelial T cells in breast cancer revealed by spatial transcriptomicsSemantic proximity Read