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Machine learning analysis reveals tumor heterogeneity and stromal-immune niches in breast cancer

2 Sept 2025

Abstract excerpt

Breast cancer is a leading cause of cancer-related mortality, with tumor heterogeneity and drug resistance posing significant challenges to treatment. We integrated single-cell RNA sequencing, spatial transcriptomics, and bulk RNA-seq deconvolution to analyze BRCA samples. Our analysis identified 15 major cell clusters, including neoplastic epithelial, immune, stromal, and endothelial populations. Notably,...

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PMID: 40897851
DOI: 10.1038/s41746-025-01967-7

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