Article

Transposable Element activation promotes neurodegeneration in a <i>Drosophila</i> model of Huntington’s disease

2020-11-19

Abstract excerpt

Huntington’s disease (HD) is a late-onset, autosomal dominant disorder characterized by progressive motor dysfunction, cognitive decline and psychiatric disturbances. The most prominent pathological manifestation is a selective loss of medium-sized spiny neurons of the striatum. The disease is caused by a CAG repeat expansion in the IT15 gene, which elongates a stretch of polyglutamine at the amino-terminal of th...

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Literature Corpus work: 17b0b399-0497-50d8-b751-381b03ce5307
DOI: 10.1101/2020.11.19.389718

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