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Article

Within-patient evolution of Pseudomonas aeruginosa populations during antimicrobial treatment.

mSphere - 28 Apr 2026

Fleres Giuseppe, Kline Ellen G, Squires Kevin M, Tate Tyler, Creager Hannah M, Shields Ryan K, Van Tyne Daria

Abstract excerpt

Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a major challenge to effective treatment. Understanding genomic adaptations during antimicrobial therapy in patients infected with this pathogen is crucial for preventing therapeutic failure. Here, we investigated the population diversity and evolution of P. aeruginosa collected longitudinally from six patients who evolved multidrug-resistant...

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Identifiers

PMID: 41837616
DOI: 10.1128/msphere.00656-25
PMCID: PMC13123702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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