Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.

doi:10.1038/s41467-022-28188-w

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Article

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.

Nature communications - 9 Mar 2022

Chung Hattie, Merakou Christina, Schaefers Matthew M, Flett Kelly B, Martini Sarah, Lu Roger, Blumenthal Jennifer A, Webster Shanice S, Cross Ashley R, Al Ahmar Roy, Halpin Erin, Anderson Michelle, Moore Nicholas S, Snesrud Eric C, Yu Hongwei D, Goldberg Joanna B, O'Toole George A, McGann Patrick, Stam Jason A, Hinkle Mary, McAdam Alexander J, Kishony Roy, Priebe Gregory P

Abstract excerpt

Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy updated during treatment. The effects of such rapid antibiotic switching on the evolution of antibiotic resistance in individual patients are poorly understood. Here we find that low-frequency antibiotic resistance mutations emerge, contract, and even go to extinction within days of changes in therapy. We analyzed...

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Identifiers

PMID: 35264582
DOI: 10.1038/s41467-022-28188-w
PMCID: PMC8907320

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