Transcriptomic Meta-Analysis and Functional Validation Identify a Long Non-Coding RNA Network That Governs Zika Virus Oncolysis in Glioblastoma Multiforme

Abstract excerpt

Glioblastoma multiforme (GBM) is the most aggressive primary brain malignancy with limited treatment options and poor clinical outcomes. There is growing interest in using Zika virus as a treatment for GBM due to its selectivity in finding and killing rapidly proliferating neural cells. Several studies reproducibly show that Zika can effectively kill GBM cells. We sought to uncover the molecular mechanisms driving...

Topics

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• Cancer-related molecular mechanisms research
• CRISPR and Genetic Engineering
• Cytomegalovirus and herpesvirus research
• Infectious Encephalopathies and Encephalitis
• interferon and immune responses
• Mosquito-borne diseases and control
• Viral Infections and Vectors
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

175fb0a2-43d7-50af-b83c-ad15b43f4843

DOI

10.20944/preprints202605.0490.v1