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Unravelling resistance mechanisms of oncolytic viruses in glioblastoma

2026-08-25

Abstract excerpt

Glioblastoma (GBM) is an aggressive primary brain tumor with a major unmet medical need. Oncolytic viruses (OVs) show promise for GBM treatment, but complete remissions remain rare. The intratumoral heterogeneity of GBM drives therapeutic escape and emergence of OV-resistant subclones. Beyond the well-characterized interferon-mediated antiviral response, mechanisms driving OV resistance remain poorly understood. T...

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Literature Corpus work
74afd852-9229-5bb7-9964-0177b96acc5f
DOI
10.64898/2026.08.24.745745
Open publication

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