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Ligation of newly replicated DNA controls the timing of DNA mismatch repair

9 Jan 2021

Abstract excerpt

Mismatch repair (MMR) safeguards genome stability through recognition and excision of DNA replication errors. 1–4 How eukaryotic MMR targets the newly replicated strand in vivo has not been established. MMR reactions reconstituted in vitro are directed to the strand containing a preexisting nick or gap, 5–8 suggesting that strand discontinuities could act as discrimination signals. Another candidate is the...

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PMID: 33417883
DOI: 10.1016/j.cub.2020.12.018

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