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Article

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.

Diabetes - 1 Feb 2010

Ortis Fernanda, Naamane Najib, Flamez Daisy, Ladrière Laurence, Moore Fabrice, Cunha Daniel A, Colli Maikel L, Thykjaer Thomas, Thorsen Kasper, Orntoft Torben F, Eizirik Decio L

Abstract excerpt

OBJECTIVE: Cytokines contribute to pancreatic beta-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to define the global expression pattern of genes, including spliced variants, modified by the cy...

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Identifiers

PMID: 19934004
DOI: 10.2337/db09-1159
PMCID: PMC2809955

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19934004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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