Article

Elongin BC complex negatively regulates AXL and marks a differentiated phenotype in melanoma

2022-07-29

Abstract excerpt

<title>Abstract</title> <p>High expression of the receptor tyrosine kinase AXL is implicated in epithelial-to-mesenchymal transition, cancer progression and therapy resistance. For example, AXL is abundant in BRAF mutant melanomas progressing on targeted BRAF/MEK inhibition. Therefore, AXL is thought to represent an attractive therapeutic target. This notwithstanding, little is known about the mechanisms governin...

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Literature Corpus work: 171f1c1e-2386-5c89-ae1d-0b9832ab3b1b
DOI: 10.21203/rs.3.rs-1808665/v1

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