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Article

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

Protein & cell - 1 Jul 2021

Xia Yu-Kun, Zeng Yi-Rong, Zhang Meng-Li, Liu Peng, Liu Fang, Zhang Hao, He Chen-Xi, Sun Yi-Ping, Zhang Jin-Ye, Zhang Cheng, Song Lei, Ding Chen, Tang Yu-Jie, Yang Zhen, Yang Chen, Wang Pu, Guan Kun-Liang, Xiong Yue, Ye Dan

Abstract excerpt

Additional sex combs-like 1 (ASXL1) interacts with BRCA1-associated protein 1 (BAP1) deubiquitinase to oppose the polycomb repressive complex 1 (PRC1)-mediated histone H2A ubiquitylation. Germline BAP1 mutations are found in a spectrum of human malignancies, while ASXL1 mutations recurrently occur in myeloid neoplasm and are associated with poor prognosis. Nearly all ASXL1 mutations are heterozygous frameshift or...

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Identifiers

PMID: 32683582
DOI: 10.1007/s13238-020-00754-2
PMCID: PMC8225741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.PMID 32683582Read ↗

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