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Article

The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.

Cell reports - 6 Jul 2021

Tang Wen-Shuai, Weng Li, Wang Xu, Liu Chang-Qin, Hu Guo-Sheng, Yin Shu-Ting, Tao Ying, Hong Ni-Na, Guo Huiling, Liu Wen, Wang Hong-Rui, Zhao Tong-Jin

Abstract excerpt

MED20 is a non-essential subunit of the transcriptional coactivator Mediator complex, but its physiological function remains largely unknown. Here, we identify MED20 as a substrate of the anti-obesity CRL4-WDTC1 E3 ubiquitin ligase complex through affinity purification and candidate screening. Overexpression of WDTC1 leads to degradation of MED20, whereas depletion of WDTC1 or CUL4A/B causes accumulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Adipose Tissue, Brown

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Identifiers

PMID: 34233190
DOI: 10.1016/j.celrep.2021.109314

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