Article

Pyocin S5 import into <i>Pseudomonas aeruginosa</i> reveals a generic mode of bacteriocin transport

2019-11-26

Abstract excerpt

Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human pathogen P. aeruginosa in animal infection models, but its import mechanism is poorly understood. Here, using crystallography, biophysical and biochemical analysis and live-cell imaging, we define the entry process of PyoS5 and reveal links to the transport mechanisms of other bacteriocins. In addition to its C-terminal pore-forming domai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1704820e-41dd-5b9d-acb8-add3288880e0
DOI: 10.1101/856047

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pyocin S5 import into <i>Pseudomonas aeruginosa</i> reveals a generic mode of bacteriocin transportDOI 10.1101/856047Read

F-type Pyocins are Diverse Non-Contractile Phage Tail-Like Weapons for Killing <i>Pseudomonas aeruginosa</i>Semantic proximity Read

A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filamentsSemantic proximity Read

Structural basis for repurposing a flexible phage tail into an Intraspecific bacterial competition weaponSemantic proximity Read

Role of R5 Pyocin in the Predominance of High-Risk <i>Pseudomonas aeruginosa</i> IsolatesSemantic proximity Read

Hoisted by Their Own Petard: Defeating Immunity Protein–Mediated Bacteriocin ResistanceSemantic proximity Read

Mechanism and Function of Type IV Secretion During Infection of the Human HostSemantic proximity Read

TattleTail: A Pyocin Prediction ToolSemantic proximity Read

Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosaSemantic proximity Read

Structural and functional analysis of pyocin S8 from <i>Pseudomonas aeruginosa</i> : requirement of a glutamate in the H-N-H motif for the DNase activitySemantic proximity Read

<i>Streptococcus mitis</i> bacteriocins drive contact-dependent lysis of <i>S. pneumoniae</i> facilitating transformation in multispecies environmentsSemantic proximity Read

Assembly and mechanisms of bacterial type IV secretion machinesSemantic proximity Read

Functional activation reveals a repressor-gated fourth type VI secretion system in clinical <i>Pseudomonas aeruginosa</i>Semantic proximity Read