Article

Functional activation reveals a repressor-gated fourth type VI secretion system in clinical <i>Pseudomonas aeruginosa</i>

2026-02-12

Abstract excerpt

Pseudomonas aeruginosa is a major opportunistic pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, we here functionally characterize a fourth system (H4-T6SS) in a clinical P. aeruginosa isolate. The H4-T6SS gene cluster is transcriptionally silent under laboratory conditions. By promoter rewiring, we demonstrate th...

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Literature Corpus work: 45222543-c57c-5016-b97b-f6fcd32e6897
DOI: 10.64898/2026.02.12.705469

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