Article

A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments

2026-03-10

Abstract excerpt

Phages can modify host cell physiology to thwart competitors. The Pseudomonas aeruginosa -specific phage DMS3 encodes Aqs1, a protein inhibitor of type IV pilus (T4P) function to prevent host cell recognition by other phages that leverage these filaments for infection. Aqs1 disrupts T4P by binding to the hexameric ATPase PilB, required to power pilus filament extension, though several mechanistic details remain u...

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Literature Corpus work: 76785bed-cc73-5b59-89f3-fce363fa88cd
DOI: 10.64898/2026.03.10.710608

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