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Developmental reversion underlies resistance to immune checkpoint blockade in kidney cancer

2026-08-06

Abstract excerpt

Despite the clinical success of immune checkpoint inhibitors (ICIs) in the management of advanced clear cell renal cell carcinoma (ccRCC), many tumors develop acquired resistance, presumed to arise from a refractory subpopulation of persister cancer cells. Previous studies have provided insights into tumor microenvironment-specific drivers of ICI resistance in ccRCC. However, the extent to which ccRCC cells underg...

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Literature Corpus work
037b13ad-9bd8-5d23-a0cc-011d18881a4a
DOI
10.64898/2026.08.05.743137
Open publication

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Developmental reversion underlies resistance to immune checkpoint blockade in kidney cancerDOI 10.64898/2026.08.05.743137
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