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Article

Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.

Nature cardiovascular research - 1 Apr 2026

Wu Chao, Li Dantong, Khetarpal Sumeet A, Yuan Zixun, Huang Shengyuan, Guerra Justin Ralph Baldovino, Li Chunyu, Zhou Qiulian, Quan Meixi, He Jiaqi, Wang Meng, Liang Huiying, Rosenzweig Anthony

Abstract excerpt

Neurological complications frequently impact morbidity, mortality and quality of life in patients with cardiovascular disease, yet the biological mediators connecting cardiovascular and neurological disease are poorly understood. Here we leverage data from 53,014 individuals with plasma proteomic profiles and 50,228 with cardiac and brain magnetic resonance imaging from the UK Biobank to identify circulating...

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PMID: 41927926
DOI: 10.1038/s44161-026-00799-2

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