Article

Deletion of <i>Trpm4</i> alters the function and expression of Na <sub>V</sub> 1.5 channel in murine cardiac myocytes

2020-07-06

Abstract excerpt

Transient receptor potential melastatin member 4 (TRPM4) encodes a Ca + -activated non-selective cation channel that is functionally expressed in several tissues including the heart. Pathogenic mutants in TRPM4 have been reported in patients with inherited cardiac diseases including conduction block and Brugada syndrome. Heterologous expression of mutant channels in cell lines indicates that these mutations can...

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Literature Corpus work: 16e0f893-0df0-5b25-8715-de1778249354
DOI: 10.1101/2020.07.06.188961

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