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Integrated computational and <i>Drosophila</i> cancer model platform captures previously unappreciated chemicals perturbing a kinase network

2018-06-11

Abstract excerpt

Drosophila provides an inexpensive and quantitative platform for measuring whole animal drug response. A complementary approach is virtual screening, where chemical libraries can be efficiently screened against protein target(s). Here, we present a unique discovery platform integrating structure-based modeling with Drosophila biology and organic synthesis. We demonstrate this platform by developing chemicals targ...

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Literature Corpus work
d6c1f9e1-5ebc-5d1a-bb0a-0e52f0ad413d
DOI
10.1101/344192
Open publication

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Integrated computational and <i>Drosophila</i> cancer model platform captures previously unappreciated chemicals perturbing a kinase networkDOI 10.1101/344192
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