Article

Lentivirus-mediated siRNA knockdown of METTL3 is involved in Alzheimer's disease

2022-05-31

Abstract excerpt

<title>Abstract</title> <p>Alzheimer's disease is the most common form of dementia in older people. The pathogenesis of AD is still uncertain, although it appears autophagy abnormalities are involved. In recent years, epigenetics, including RNA N6-methyladenosine (m6A) methylation, has been shown to be involved in the pathogenesis of neurodegeneration. However, how RNA methylation may be involved in the pathogene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6dce56eb-dac6-5081-94cb-74d3f2ee2d88
DOI: 10.21203/rs.3.rs-1244467/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lentivirus-mediated siRNA knockdown of METTL3 is involved in Alzheimer's diseaseDOI 10.21203/rs.3.rs-1244467/v1Read

Epitranscriptome Changes in Neurodegenerative Diseases and the Potential Strategy for the TherapeuticsSemantic proximity Read

Reduced levels of N6-methyladenosine in RNA of peripheral blood mononuclear cells from patients with Alzheimer's diseaseSemantic proximity Read

Mitochondrial dysfunction-induced KDM5A degradation impairs adult hippocampal neurogenesis in Alzheimer’s diseaseSemantic proximity Read

m⁶A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer’s diseaseSemantic proximity Read

Decreased MEF2A Expression Regulated by Its Enhancer Methylation Inhibits Autophagy and May Play an Important Role in the Progression of Alzheimer’s DiseaseSemantic proximity Read

Abnormal epigenetic modification of lysosome and lipid regulating genes in Alzheimer’s diseaseSemantic proximity Read

Dynamics of N6-methyladenosine modification during Alzheimer's disease developmentSemantic proximity Read

A New Discovery of MicroRNA-455-3p in Alzheimer’s DiseaseSemantic proximity Read

The m6A RNA methylation exerts a neuroprotective function by regulating the expression of α-synucleinSemantic proximity Read

Novel microRNA-455-3p mouse models to study Alzheimer’s disease pathogenesisSemantic proximity Read

LncRNA RP11-59J16.2 Aggravates Apoptosis and Increases Tau Phosphorylation via Inhibiting MCM2 On The AD SH-SY5Y Cell Model Induced By Aβ.Semantic proximity Read

Advances with RNA interference in Alzheimer's disease research.Semantic proximity Read