Article
The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2009
Dejima Katsufumi, Murata Daisuke, Mizuguchi Souhei, Nomura Kazuko H, Gengyo-Ando Keiko, Mitani Shohei, Kamiyama Shin, Nishihara Shoko, Nomura Kazuya
Abstract excerpt
Although the solute carrier 35B1 (SLC35B1) is evolutionarily conserved, its functions in metazoans remain unknown. To elucidate its function, we examined developmental roles of an SLC35B1 family gene (HUT-1: homolog of UDP-Gal transporter) in Caenorhabditis elegans. We isolated a deletion mutant of the gene and characterized phenotypes of the mutant and hut-1 RNAi-treated worms. GFP-HUT-1 reporter analysis was...
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