Article

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

2023-07-24

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death in the world. In most cases, drug resistance and tumor recurrence are ultimately inevitable. One obstacle is the presence of chemotherapy-insensitive quiescent cancer cells (QCCs). Identification of unique features of QCCs may facilitate the development of new targeted therapeutic strategies to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 169796b9-0ead-5d08-9aad-c2fc58cbf735
DOI: 10.21203/rs.3.rs-3144900/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cellsDOI 10.21203/rs.3.rs-3144900/v1Read

Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancerSemantic proximity Read

Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancerSemantic proximity Read

Identification of a Unique Subpopulation of Mucosal Fibroblasts in Colorectal Cancer with Tumor- Restraining CharacteristicsSemantic proximity Read

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of QuiescenceSemantic proximity Read

ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt PathwaySemantic proximity Read

Analyzing the Impact of ATF3 in Tumorigenesis and Immune Cell Infiltration of Ovarian Tumor: A Bioinformatics StudySemantic proximity Read

Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cellsSemantic proximity Read

A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activitySemantic proximity Read

UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs.Semantic proximity Read

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancerSemantic proximity Read

Single-cell RNA sequencing and machine learning provide candidate drugs against drug-tolerant persister cells in colorectal cancerSemantic proximity Read

FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating CellsSemantic proximity Read