Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells

13 Jan 2021

Abstract excerpt

Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, induces overexpression of CD44v6, MDR1, and oncogenic transcription/translation factor Y-box-binding protein-1 (YB-1)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33451103
DOI: 10.3390/ijms22020753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating CellsPMID 33451103Read ↗

lncRNA TUG1 Facilitates Colorectal Cancer Stem Cell Characteristics and Chemoresistance by Enhancing GATA6 Protein StabilitySemantic proximity Read ↗

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAomeSemantic proximity Read ↗

Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugsSemantic proximity Read ↗

Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.Semantic proximity Read ↗

Establishment of Highly Tumorigenic Human Colorectal Cancer Cell Line (CR4) with Properties of Putative Cancer Stem CellsSemantic proximity Read ↗

PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.Semantic proximity Read ↗

Cancer stem cell–associated miRNAs serve as prognostic biomarkers in colorectal cancerSemantic proximity Read ↗

Molecular Biomarkers and Signaling Pathways of Cancer Stem Cells in Colorectal CancerSemantic proximity Read ↗

Role and molecular mechanism of stem cells in colorectal cancer initiationSemantic proximity Read ↗

CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancerSemantic proximity Read ↗

CircPOFUT1 fosters colorectal cancer metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1Semantic proximity Read ↗

Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.