Article

Experimental evolution to identify undescribed mechanisms of resistance to a novel cationic peptide antibiotic

2020-12-16

Abstract excerpt

A key strategy for resolving the antibiotic resistance crisis is the development of new drugs with antimicrobial properties. The engineered cationic antimicrobial peptide WLBU2 (also known as PLG0206) is a promising broad-spectrum antimicrobial compound that has completed Phase I clinical studies. It has activity against Gram-negative and Gram-positive bacteria including infections associated with biofilm. No defi...

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Literature Corpus work: 1694dd56-868a-56d5-a56c-89c1c123ecf1
DOI: 10.1101/2020.12.16.423161

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