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Article

A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide.

Nature communications - 12 Aug 2026

Mulkern Adam J, Vu Thu-Hien, Popella Linda, Kerrinnes Tobias, Ðurica-Mitić Svetlana, Halte Manuel, Dresbach-Hill Kylee, Uhlemann Anne-Catrin, Uphoff Stephan, Barquist Lars, Vogel Jörg, Galardini Marco

Abstract excerpt

The rise of antimicrobial resistance (AMR) among human pathogens is a serious threat to global health, demanding novel treatment strategies. Antibiotics based on programmable antisense oligomers (asobiotics) offer an attractive solution, as their specificity can be quickly updated to target resistant bacteria. To understand the genetic architecture of resistance to asobiotics, we used laboratory evolution assays...

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Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Klebsiella pneumoniae

Share to Membrane Transport Proteins

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Source

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Identifiers

PMID: 42586984
DOI: 10.1038/s41467-026-76357-y
PMCID: PMC13469510

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