Article
Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects.
eLife - 10 May 2022
Solman Maja, Blokzijl-Franke Sasja, Piques Florian, Yan Chuan, Yang Qiqi, Strullu Marion, Kamel Sarah M, Ak Pakize, Bakkers Jeroen, Langenau David M, Cavé Hélène, den Hertog Jeroen
Abstract excerpt
Gain-of-function mutations in the protein-tyrosine phosphatase SHP2 are the most frequently occurring mutations in sporadic juvenile myelomonocytic leukemia (JMML) and JMML-like myeloproliferative neoplasm (MPN) associated with Noonan syndrome (NS). Hematopoietic stem and progenitor cells (HSPCs) are the disease propagating cells of JMML. Here, we explored transcriptomes of HSPCs with SHP2 mutations derived from...
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