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Article

Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish.

PloS one - 1 Jan 2015

Shiau Celia E, Kaufman Zoe, Meireles Ana M, Talbot William S

Abstract excerpt

Interferon regulatory factor 8 (Irf8) is critical for mammalian macrophage development and innate immunity, but its role in teleost myelopoiesis remains incompletely understood. In particular, genetic tools to analyze the role of Irf8 in zebrafish macrophage development at larval and adult stages are lacking. We generated irf8 null mutants in zebrafish using TALEN-mediated targeting. Our analysis defines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25615614
DOI: 10.1371/journal.pone.0117513
PMCID: PMC4304715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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