Article

Serotonin drives selective hepatic insulin resistance via HTR2A and HTR2B

2026-03-04

Abstract excerpt

<title>Abstract</title> <p> Selective hepatic insulin resistance is characterized by preserved lipogenesis despite the failure to suppress gluconeogenesis, yet the detailed molecular mechanisms underlying this paradox remain incompletely understood. Here, we identify serotonin as an insulin independent regulator that differentially regulates hepatic lipid and glucose metabolism in insulin resistant states. Serot...

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Identifiers and source

Literature Corpus work: 1658ee88-e305-5fed-ad12-d54f66e9fa37
DOI: 10.21203/rs.3.rs-8819291/v1

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