Article
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.
The Journal of clinical investigation - 1 Feb 2009
Semple Robert K, Sleigh Alison, Murgatroyd Peter R, Adams Claire A, Bluck Les, Jackson Sarah, Vottero Alessandra, Kanabar Dipak, Charlton-Menys Valentine, Durrington Paul, Soos Maria A, Carpenter T Adrian, Lomas David J, Cochran Elaine K, Gorden Phillip, O'Rahilly Stephen, Savage David B
Abstract excerpt
Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic steatosis. Increased hepatic lipogenesis contributes to both of these problems. Because insulin fails to suppress gluconeogenesis but continues to stimulate lipogenesis in both obese and lipodystrophic insulin-resistant mice, it has been proposed that a selective...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.