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Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

6 Jun 2024

Abstract excerpt

Mutation of the ATL1 gene is one of the most common causes of hereditary spastic paraplegia (HSP), a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Atlastin-1, the protein encoded by ATL1, is one of three mammalian atlastins, which are homologous dynamin-like GTPases that control endoplasmic reticulum (ER) morphology by fusing tubules to...

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PMID: 38851544
DOI: 10.1016/j.nbd.2024.106556

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