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Article

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.

Experimental cell research - 15 Nov 2016

Zhao Guohua, Zhu Peng-Peng, Renvoisé Benoît, Maldonado-Báez Lymarie, Park Seong Hee, Blackstone Craig

Abstract excerpt

Atlastins are large, membrane-bound GTPases that participate in the fusion of endoplasmic reticulum (ER) tubules to generate the polygonal ER network in eukaryotes. They also regulate lipid droplet size and inhibit bone morphogenetic protein (BMP) signaling, though mechanisms remain unclear. Humans have three atlastins (ATL1, ATL2, and ATL3), and ATL1 and ATL3 are mutated in autosomal dominant hereditary spastic...

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Source

Identifiers

PMID: 27669642
DOI: 10.1016/j.yexcr.2016.09.015

Genes

ATL1
ATL3
ATL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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